In the hopes that some of the spammers will remove me from their lists, instead of deleting their bulk inquiries (I can tell that they're bulk, since they'll be repeat inquiries across various types of domains, e.g. short acronyms or dictionary domains, etc.), I'll reply with "F*ck off, spammer!" (several times, if need be). Since some of them pretend to be women, using female names, I'll even use "F*ck off, spamming ho!"